Impact of grip strength and balance function on the exercise capacity in pulmonary hypertension

Abstract Funding Acknowledgements Type of funding sources: None. 【Background】 Patients with pulmonary hypertension (PH) suffer from poor exercise capacity due to impaired oxygenation or reduced cardiac output. However, the relationship between and physical functions remains unclear. 【Purpose】 The purpose this study is investigate in hypertension. 【Methods】 From February 2018 June 2020, 94 patients (61.3 ± 14.7 years old, 69.1% females) group 1/3/4/5 PH underwent catheterization, 6-minute walking distance (6MWD), function measurements simultaneously. was measured using muscle strength (grip strength, knee extension strength), balance (one leg standing time), short performance battery (SPPB). Exercise by 6MWD. 【Results】 cohort consists 22/8/60/4 (23.4%/8.5%/63.8%/4.3%) PH, respectively. average age each 50.7/64.7/63.1/66.0 A total 194 were evaluated employed multivariate logistic regression analysis adaptive-LASSO methods 6MWD (476.2 107.5m) as a dependent variable. WHO functional class (class II: standardized β=-0.35, 95% confidence interval (CI) [-0.54 - -0.16], p < 0.001), III: β=-0.60, 95%CI [-0.90 -0.30], mixed venous oxygen saturation (SvO2: β=0.11, [0.03 0.19], = 0.008), vascular resistance (PVR: β=-0.16, [-0.25 -0.07], grip (β=0.20, [0.09 0.31], one time (β=0.10, [0.00 0.20], 0.049) , 4m gait speed test (β=-0.28, [-0.36 -0.19], 0.001) associated 【Conclusions】 Grip function, well SvO2 PVR,